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pKa PRO

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Measure acid dissociation constants of water-soluble and insoluble compounds, rapidly and reliably.

pKa PRO allows you to accurately quantify compound pKa values, even in the presence of sample impurities. Capillary electrophoresis and fixed-wavelength UV absorbance provide precise detection, while software seamlessly integrates data for simple reporting.

Preferred by seven of the top 10 pharmaceutical companies, this technology has been extensively validated across the industry. Predefined separation methodologies ensure you get consistent results across multiple runs and from lab to lab.

Choose the buffer plate for your specific application and you’re ready to go.

  • Measure pKa across pH 1.7–11.2

  • Generate aqueous measurements without cosolvents

  • Define overall charge against pH, for calculating isoelectric point (pI value)

  • Chiral analysis

    A swift and practical workflow for screening enantiomeric forms of chiral substances.

    Check enantiomeric form without the time and cost of chromatography. Parallel chiral separation via automated capillary electrophoresis gives you the resolution to assess drug efficacy and safety with confidence.

    Our universal and tunable capillary array significantly enhances sample throughput while minimizing reagent costs and development times. There are no column stationary phase chemistries to change. Simply choose the buffers and diluents that correspond to your specific application and you’re ready to go.

    • Set separation selectivity simply by exchanging buffer additives

    • Lower your capillary volumes to reduce reagent and sample consumption

    • Screen different sample/additive combinations in a single experiment

    • Choose neutral- or charged-cyclodextrin chiral buffer additives

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  • pKa/pl analysis

    Determine compound solubility and membrane permeability with limited sample, for fast and flexible ADMET research and product formulation.

    Until now, it required a lot of your precious compound to determine its acid dissociation constant and/or isoelectric point. Tests have also typically been sensitive to compound structure and prone to compound precipitation, while saddling researchers with complex data analysis.

    The pKa PRO™ system changes all that, giving you a straightforward way to generate impurity data that’s not biased by compound structure. What’s more, the system’s extreme sensitivity means you can measure difficult-to-dissolve compounds in aqueous environments, without cosolvents.

    Simply choose the buffers and diluents that correspond to your specific application and you’re ready to go.

    • Identify and isolate compound degradants or impurities

    • See pI plus overall compound charge as a function of pH

    • Plot compound mobility against molecular weight to predict compound valency

    • Measure ionic mobility without intimate knowledge of sample concentration

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